Simparica TRIO^® Chewable Tablets for Dogs

SIMPARICA TRIO is for the prevention of heartworm disease and for the treatment and control of roundworm and hookworm infections. SIMPARICA TRIO kills adult fleas and is for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with lone star ticks, Gulf Coast ticks, American dog ticks, black‐legged ticks, and brown dog ticks for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. SIMPARICA TRIO is for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Active Ingredients: moxidectin, pyrantel pamoate, sarolaner

Rx: Available direct to customers with valid prescriptions: See service area map

Dosage and Administration: SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 μg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). SIMPARICA TRIO can be offered to the dog with or without food. Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.

Warnings: Not for use in humans. Keep this and all drugs out of reach of children. Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.

Caution: For oral use in dogs only.
Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs.

Storage: Store at or below 30° C (86° F)

Shipping: Ships via Ground. Overnight shipping available upon request for a $25 shipping fee on orders up to 5 lbs. Heavier orders require a custom quote. Overnight shipping is not eligible for free shipping.