Date published: 2025-9-6

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SMZ TMP Tablets

by Generic
5.0(9)
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Multi-species combination antibiotic and antimicrobial
    • Multi-species antibiotic
    • Contains Sulfamethoxazole and Trimethoprim
    • Supplied as 480 mg or 960 mg tablets individually or in a 100 or 500 count bottle
    • Requires a veterinarian's prescription
Catalog #DescriptionPriceQtyAutoshipCARTFAVORITES
sc-362986Rx
100 tabs, 480 mg
$11.95
sc-362988Rx
100 tabs, 960 mg
$19.59
sc-362987Rx
500 tablets, 480 mg
$47.97
sc-362989Rx
500 tablets, 960 mg
$39.15
sc-551039Rx
500 tabs, 960 mg
$49.95
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SMZ TMP is an multi-species antibiotic for treatment of bacterial and protozoal infections.

Alone, sulfonamides are bacteriostatic agents and trimethoprim is bactericidal, but when used in combination, the potentiated sulfas are bactericidal. SMZ with TMP has fairly broad spectrum of activity, such as gram-positive bacteria including most streptococci, many strains of staphylococcus, and Nocardia. Many gram-negative organisms of the family Enterobacteriaceae are susceptible to the potentiated sulfas. Some protozoa (Pneumocystis carinii, Coccidia, and Toxoplasma) are also inhibited by the combination.

Supplied individually and as either a bottle containing 100 or 500 tablets in concentration of either 480 mg or 960 mg.
A veterinarian's prescription is required for purchase.

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After mixing SMZ's with water and mixing it in feed, can it be stored in the refrigerator for a few hours?

Asked by: Julie343
We would suggest reaching out to the manufacturer. Thank you, SCAH Team
Answered by: Mandy
Date published: 2024-01-03
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Rated 5 out of 5 by from Work on a wide range of infections; good to haveI've had vets prescribe these for a range of infection issues from wounds to a persistent cough. They're easy to administer (in my experience, they're best delivered orally in a syringe with a little water) and are good to have around.
Date published: 2018-09-15
Rated 5 out of 5 by from Prescription medicationI am thrilled to pieces that Santa Cruz can also fill all my prescription needs ! And the speedy shipping is a priority for me when I have a sick horse . Santa Cruz is tops in every way, including affordable prices.
Date published: 2019-06-11
Rated 5 out of 5 by from Good for a variety of minor infectionsGreat for treating minor infections, but can be tough to administer if you have a difficult horse. Best luck I've had is mixing with a little bit of water in a syringe and giving the paste orally.
Date published: 2018-02-20
Rated 5 out of 5 by from Great product!Great to have on hand for minor infections. I mix the tablets with a little water to make a paste, and then I can easily administer it to my horses. The tablets dissolve very easily and fast.
Date published: 2018-03-14
Rated 5 out of 5 by from Owner of WillowWind StableI order Meds from Santa Cruz all the time, and SMZ Tablets I go through like candy, when I do us them I need 20 per day per horse for 10 Days so I usually order a 1000 tabs at a time.
Date published: 2020-01-04
Rated 5 out of 5 by from Good valueUnder veterinary supervision great basic antibiotic . Easy to dissolve and disguise with a little caro syrup in an oral syringe.
Date published: 2025-08-04
Rated 5 out of 5 by from Fantastic ordering experienceSuperior customer service and ease in the RX filling process. This company is the best!!
Date published: 2017-09-12
Rated 5 out of 5 by from Good to have on handGood to have on hand for snotty noses or minor infections. Cheap and easy to administer.
Date published: 2017-09-19
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SMZ TMP Tablets is rated 5.0 out of 5 by 10.
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