Zycosan™ (pentosan sulfate) Injection

Zycosan is indicated for the control of clinical signs associated with osteoarthritis in horses. Zycosan contains 250 mg/ml pentosan polysulfate sodium.

Osteoarthritis (OA) is the leading cause of lameness in horses. Most horses will experience lameness at some point in their lives. OA can occur in any joint in the horse’s body, including the carpus, hocks, fetlocks, stifles, and other weight bearing joints, as well as the neck and back. It can significantly impact a horse’s overall health and athletic ability. Horse arthritis medicine can help.

For intramuscular use in horses only.

Active Ingredients per ml: 250 mg of pentosan polysulfate sodium

Inactive ingredients per ml: 10 mg sodium metabisulfite, 6.27 mg potassium phosphate dibasic, 1.905 mg potassium phosphate monobasic, sodium hydroxide and hydrochloric acid (to adjust pH), and water for injection.

Rx: Available direct to customers with valid prescriptions: See service area map

Indications: For the control of clinical signs associated with osteoarthritis in horses. Requires a veterinarian's prescription.

Dosage and Administration: Administer 3 mg/kg (1.4 mg/lb) by intramuscular injection once weekly for four weeks (for a total of four doses). Zycosan is provided in a single use vial and does not contain a preservative. Discard unused vial contents.

Contraindications: Horses with hypersensitivity to pentosan polysulfate sodium or any of the inactive ingredients in Zycosan should not receive Zycosan. Do not use Zycosan concurrently with other anticoagulant drugs. Do not use in horses with clotting disorders or within 24 hours of surgical procedures (see Warnings and Precautions).

Warnings and Precautions:

• User: Not for use in humans. Keep out of reach of children. Pentosan polysulfate sodium is a weak anticoagulant. Caution should be used when administering Zycosan if you are taking an anticoagulant. In case of accidental self-injection, seek immediate medical attention. If product comes into contact with skin, rinse skin thoroughly with water and seek medical attention if needed.
• Animal: Zycosan has been shown to prolong coagulation parameters up to 24 hours after injection, therefore caution should be used when administering this drug before or after strenuous activities (see Target Animal Safety). The concurrent use of NSAIDs with Zycosan has not been evaluated. Caution should be used if NSAIDs are concurrently administered. Horses concurrently treated with Zycosan and NSAIDs should be monitored for hemorrhage or other clinical signs of abnormal bleeding.
• The safety of long-term repeat use of Zycosan has not been evaluated.
• The safe use of Zycosan has not been evaluated in breeding, pregnant, or lactating horses.

Storage: Store at room temperature 68-77° F (20-25° C), with excursions to 59-86° F (15-30° C).

Shipping: Ships via Ground. Overnight shipping available upon request for a $25 shipping fee on orders up to 5 lbs. Heavier orders require a custom quote. Overnight shipping is not eligible for free shipping.