UltraCruz® Roller Bottles are manufactured in a class 100,000 clean room using a process that provides high impact resistance. Sterilized by gamma irradiation and nonpyrogenic, the roller bottles feature an easy on/off cap, vents for continuous gas exchange and are marked with easy-to-read graduations. Roller bottles are used for both research and manufacturing applications including growing of mammalian cells for purposes of virus propagation and bioproduct production. Roller bottles are compatible with manual or automatic filling systems.